Stemonamide synthetic intermediates and its pharmaceutical compositions for prevention and treatment of pancreatic cancer
Lead compound for cancer therapy such as pancreas, liver, colon, and stomach. When the compound was administered to nude mice injected with a human pancreatic cancer cell line, it retarded tumor growth by increasing apoptotic cell numbers and decreasing proliferating cell numbers by inhibiting Pim kinases. Stemonamide can inhibit in vitro activities of Pim-3 kinase and its related kinases such as Pim-1 and Pim-2. Pim kinase inhibitors can be effective with fewer toxicities than Akt inhibitors, for the treatment of various cancers, particularly pancreatic cancer, which is often complicated with diabetes mellitus.
- Uses & Applications
- Cancer Therapy Product
- Application/Publication No.
- Patent Filed
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